Latest News, Grants & Research Reports
Read our latest news, blog posts and research updates right here
Research partly funded by Neuroblastoma UK leads to an innovative stem cell model providing insight into childhood cancer origins
Researchers from the University of Sheffield and St. Anna Children’s Cancer Research Institute have created a model designed to investigate the origins of neuroblastoma, a cancer primarily affecting infants and young children. The findings offer hope for the creation of tailored treatments which treat aggressive neuroblastomas and minimise the adverse effects experienced by patients from existing therapies.
New research suggests potential combination therapy option for children with neuroblastoma to prevent resistance to treatment
New research published by Professor Suzanne Turner and led by Dr Perla Pucci in her group at the University of Cambridge Department of Pathology and CRUK Cambridge Centre Paediatric Cancer Programme, has suggested a new target for combination treatment of neuroblastoma and other cancers alongside ALK tyrosine kinase inhibitors (ALK TKI). Resistance to ALK TKI is a challenge and so additional targets for treatments that can be used in combination with ALK TKI are urgently needed.
The Power of Collaboration to Find a Cure…
In 2019, Neuroblastoma UK joined forces with childhood cancer charities The Bradley Lowery Foundation and Niamh's Next Step to support more vital research into neuroblastoma.
6th Neuroblastoma UK Research Symposium focuses on the biology of neuroblastoma, aiming for more effective and less toxic treatments for children
It was sold out two months in advance, so it was no surprise to see a packed auditorium at Selwyn College Cambridge for the 6th Neuroblastoma UK Research Symposium on 21st and 22nd March 2024. Over 130 scientists and clinicians attended from across Europe, US, and further afield, including world leading experts in pre-clinical and clinical neuroblastoma research.
Encouraging results from the study investigating the role of Enhancer of Zeste homolog 2 (EZH2) and Natural Killer cells in Neuroblastoma
In 2023, Dr Gao, working with Prof Juliet Gray and Dr Zoë Walters at the University of Southampton, aimed to determine the role of natural killer cell- mediated anti-tumour effects in neuroblastoma, after treatment with EZH2. The objectives of the study were to look at the correlation between EZH2 protein expression and the surface expression of natural killer ligands in neuroblastoma cells, and to determine if the natural killer cells induced cytotoxicity that could be enhanced in the neuroblastoma cell lines with EZH2 inhibitors.
Trustees Week 2023
This Trustees Week, we shine the spotlight on Dr Kate Wheeler and Dr Deb Tweddle, our Medical Trustees for over 10 years.
Deb and Kate attended the SIOPEN (international Society of Paediatric Oncology - European Neuroblastoma Group) annual general meeting in Ljubljana, Slovenia from 4th to 6th October 2023. Their visit was supported by Eusa Pharma.
Celebrating neuroblastoma research
This Childhood Cancer Awareness Month, we joined the research team at the University of Cambridge to celebrate their vital research into neuroblastoma. Dr Kirsty Ferguson organised this fabulous opportunity for our team and supporters to visit the lab, and tells us more about the day.
Recognising researchers this International Women's Day
International Women's Day (8th March) is a global day celebrating the social, economic, cultural, and political achievements of women.
We celebrate the female scientists who work tirelessly to fight childhood cancer - we asked three of our funded researchers about what motivates them in their work to improve treatment for neuroblastoma.
Research Grants - a 2022 update
This year we reviewed the current results of the research initially funded by Neuroblastoma UK from 2010 to 2017. Our Symposiums over the last ten years have brought together researchers to share their work and highlight topics, examples are: new treatments, advances in differentiation therapy, genetic landscape of neuroblastoma , the role of MYC gene and micro RNA signatures.
Dr Jinhui Gao, a Research Fellow will be looking into, ‘Investigating the role of Enhancer of Zeste homolog 2 (EZH2) and Natural Killer cells in Neuroblastoma’.
Intensive chemotherapy used in the treatment for high-risk neuroblastoma does not cure all children and has significant side effects and long-term toxicity, so it is imperative that we continue to look for new treatments. One area is to improve the efficacy of immunotherapy. Anti-GD2 immunotherapy is now a mainstay in the therapy of neuroblastoma. Natural killer cells play a major role in the effectiveness of anti-GD2 immunotherapy and EZH2 alters the action of natural killer cells. This pilot study will investigate the benefit of combining EZH2 inhibitors and anti-GD2 immunotherapy.